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Map3k14 deficiency disrupts NADPH production, induces the accumulation of ROS in cells, and eventually leads to the autophagic degradation of hexokinase 2

doi: 10.1007/978-1-4020-6486-9_11 45 KleinJ

And what the authors conclusion was, was that because the total mortality was just starting to diverge at the eight year mark, and because they had a plausible reason for it, that the cancer was exploding