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2.5 Treatment Cognitive-behavioral therapy (CBT) is a well-established standard treatment for addressing cognitive impairment caused by METH abuse ( In addition to behavioral therapies, pharmacological approaches have demonstrated potential benefits

*Correspondence: Koji Hase, [email protected] This article was submitted to Mucosal Immunity, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Folate can improve endothelial functions in coronary artery diseases through a mechanism that does not affect the Hcy level [54]

In one study, subjects immediately reported feeling "sleep pressure" after DSIP administration, and total sleep time increased by 59% within 130 minutes compared to placebo