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Many individuals, particularly those under chronic stress or with digestive issues, do not absorb oral B12 efficiently

In the overall Japanese population, about 57% of individuals are homozygous for the normal allele (sometimes termed ALDH2*1), 40% are heterozygous for glu487lys, and 3% are homozygous for glu487lys

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Differential features were assessed using parametric ( t test) and non-parametric (Wilcoxon rank sum) statistical tests to account for the degree, direction, and rank of differences between the patient and control groups