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Lean mass preservation remains relatively good because AOD 9604 selectively targets adipose tissue while tirzepatide maintains favorable lean-to-fat loss ratios

The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation

they are not FDA-approved for general consumer use, retail sale or recreational selfadministration and are dispensed exclusively through licensed pharmacies to patients under active clinical care

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The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested