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Nature (1987) 325(6106):7336.10.1038/325733a0 107 GlennerGGWongCW

A therapeutic dose is 24 grams EPA+DHA daily, with EPA predominant

The plasma insulin levels were detected by ELISA using a mouse insulin ELISA kit (Catalog # EMINS

While individuals may choose to continue supplementation beyond this 16-week period, most studies have been limited to around 16 weeks

Therefore, DON treatment can not only reduce the self-renewal potential and metastatic ability of pancreatic ductal adenocarcinoma (PDAC) tumor cells but also lead to extensive remodeling of the tumor extracellular matrix (ECM), promoting the infiltration and activation of CD8 + T cells (Sharma et al., 2020)