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On the other hand, cysteine needs to be imported from plasma into the brain in order to synthetize glutathione (GSH), and this import is mediated by system X C (Figure 1)

compensatory pathways restored RNA and protein synthesis

The thiol group in the former allows the glutathione molecule to provide what is known as a reducing equivalent, which means the ability to donate one electron to other molecules rendered unstable and highly reactive due to a lack of balanced electron pairs

While showing evidence of metabolic target engagement and tumor responses in select patients, toxicities including peripheral neuropathy and lactic acidosis have been dose-limiting