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doi:10.1159/000109829

However, while 16 days of L-citrulline supplementation at a daily dose of 3.4 g significantly increased plasma citrulline, arginine, and nitrite levels, and increased muscle oxygenation during moderate-intensity (70% VO 2 peak) exercise, there were no superior effects on time-to-exhaustion during high-intensity (90% VO 2 peak) exercise

(More than ninety per cent of such treatments will not be F.D.A.-approved.) In recent years, Montana state laws have gone even further, granting all patients access to an even wider array of experimental treatments

PubMed Silverstein FE, et al

This seems to be the case for short-term exposure to antimicrobials, but studies of long-term antibiotic use have reported that perturbations in gut microbiota and resistome can have either long-lasting irreversible effects or can persist for longer periods 16,18,25