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The second stage is Trem2-dependent and is marked by increased expression of genes involves in lipid metabolism and phagocytic pathway genes (e.g., Lpl, Cst , and Cd9 ), causing excessive inflammatory responses and neurodegeneration (Keren-Shaul et al., 2017

Antioxidants (Basel) 9(10):909 Rius-Prez S et al (2020) PGC-1, inflammation, and oxidative stress: an integrative view in metabolism