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Usually, moderate and severe cases show signs and symptoms during infancy

A partially purified leaf enzyme with DHAR activity was subsequently reported, but was considered likely to be cytosolic (Foyer and Halliwell 1977)

J Can Respir J

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In mice in which genetically engineered deletion of xCT leads to deficiency in the glutamate/cystine antiporter system x, the prominent reduction of extrasynaptic L-glu is associated with a robust resistance of dopaminergic neurons against 6-hydroxydopamine-induced neurodegeneration (Massie et al., 2011), possibly as a result of decreased excitotoxicity