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While citicoline has been found safe at the therapeutic doses being currently administered, an ideal clinical study to evaluate the neurotherapeutic effects of citicoline in glaucoma may be difficult to perform owing to the inherent issues in the natural history of glaucoma such as a long term and rather variable progression curve, the difficulty to predict disease severity and glaucoma risks in terms of elevated IOP, variable and unclear age of onset, involvements of the brain apart from the eye, the lack of consensus in cupping paradigm, the potential role of endothelial dysfunction, the systemic effects on disease onset and progression, role of stress and anxiety, and other psychosomatic involvements (Weinreb, 2007)

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Diabetes Care 25 , 11351141 (2002)