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Indeed, the administration of a single dose of vitamin B-6 (600 mg/kg, subcutaneous) immediately into cecal ligation and perforation-induced mid-grade septic rats could remarkably reduce acute oxidative damage in the liver [30]

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However, due to pleiotropic roles of CEP192 in centriole biogenesis, centrosome maturation and microtubule nucleation, this impact of CEP192 depletion on Aurora-A may be indirect