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In summary, despite the challenges posed by tumour heterogeneity, diverse microenvironmental adaptability, and safety concerns, targeted therapies aimed at ROS and related PCD pathways offer new perspectives for precision medicine in breast cancer

10.1056/NEJM198812153192401

Interestingly, inherited mitochondriopathies do not usually present with parkinsonian features [with some notable exceptions, such as in POLG mutation carriers (Ma et al., 2020)]