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Oxidative stress impairs SIRT3 activity and transcription by regulating protein carbonylation and transcriptional function of peroxisome proliferator-activated receptor- coactivator-1, leading to mitochondrial dysfunction and activation of the mitochondrial apoptotic pathway via optic atrophy 1 to induce cell death of vitiligo melanocytes [32]

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Methodology: A systematic review and a meta-analysis were performed by searching 5 electronic databases and retrieving 2979 articles from which 29 qualified as included studies for reporting 37 biomarkers that were grouped into 8 preclinical DCM biomarker models