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Gut dysbiosis and reactive oxygen species (ROS)-induced oxidative stress contribute to the accumulation of -syn, which subsequently propagates to the brain via the vagus nerve, thereby establishing a gut-brain axis mechanism in disease progression (Soni et al., 2024)

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Also, a significant rise in weight loss was observed in humans following consumption of a high dose of green tea for 12 weeks

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In contrast, aged animals, while still benefiting significantly from 1-MX, may experience a relatively smaller improvement due to the pre-existing age-related decline in these neural processes