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and RB1: Retinoblastoma 1.

In line with this, mTOR inhibition will lead to the autophagic degradation of the Notch1 receptor, reducing the tumorigenicity of GSCs [173]

Methods Ethics statement This study was carried out in strict accordance with the recommendations of the Regulations for the Administration of Affairs Concerning Experimental Animals of the State Science and Technology Commission

While in one study the PINK1/Parkin system was found not to be functional in human peripheral blood mononuclear cells (Bradshaw et al, 2021), another study found that the knockout of Pink rather promotes the differentiation into Th1 cells in mice (Mei et al, 2023)