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36 HaydenD.JenningsA.MullerC.PascoeD.BublitzR.WebbH.et al

10.2337/db22-0515 26 DongS.LiuS.LiQ

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The cystine/glutamate antiporter system Xc , a heterodimer composed of SLC7A11 and SLC3A2 on the cell membrane surface, takes up extracellular cystine in exchange for intracellular glutamate in a 1:1 ratio [9]