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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Data availability Some datasets generated during and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request if patient confidentiality is preserved

+ In priority order: B5 (pantothenic acid) direct co-factor in cortisol synthesis, the most specifically important for adrenal function

Beyond B12, patients on semaglutide should consider monitoring iron, folate, calcium, and vitamin D levels, as reduced appetite may lead to lower overall nutrient intake