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AST, Aspartate transaminase

Increased expression of H3.3 in PBMCs from RA patients has been associated with histone acetylation markers ( CCL2 promoter ( Future research should further investigate the specific mechanisms of trained immunity in RA, particularly how epigenetic reprogramming and metabolic shifts coordinate to regulate monocytes, macrophages, and possibly non-immune cells

The Dimerization and Docking (D/D) domain which is the characteristic feature of these regulatory subunits (RII) has been classically used to detect cellular AKAPs [30]