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Journal of Cardiovascular Development and Disease, 11 (12), 377

Calcium- and endothelial-mediated vascular smooth muscle relaxation in rabbit aorta

We found that the injection of RESV reduced the changes caused by the STZ-induced stimulation of TRPV4, which in turn increased mechanical/thermal neuropathic pain, cytosolic Ca 2+ influx, TRPV4 current density, oxidants (lipid peroxidation, mitochondrial ROS, and cytosolic ROS), and apoptotic markers (caspase-3, -8, and -9)

824 Specifically knockout of NAT10 or inhibiting NAT10 activity in the kidney significantly inhibits ac4C RNA modification and reduces renal I/R injury