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Specifically, we employed a two-stage, screen/counter-screen strategy

Betaine improves METH-induced depressive-like behavior and cognitive impairment by alleviating neuroinflammation via NLRP3 inflammasome inhibition

doi: 10.1016/j.ejphar.2008.03.008 239

Proc Natl Acad Sci U S A 2011;108:1831318317

The permutation plot then displays the correlation coefficient between the original y-variable and the permuted y-variable on the x-axis versus the cumulative R2 and Q2 on the y-axis and draws the regression line