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Ammonia-mediated astrocyte activation exacerbates brain injury in MMAemia, as demonstrated by elevated glial fibrillary acidic protein expression in cortical, hippocampal, and striatal regions, along with increased TNF- and IL-1 levels in murine models receiving combined ammonia and MMA treatment (Gabbi et al

This increase is likely linked to the consumption of a high-energy diet, which appears to promote the mRNA expression of the FABP3 and APOB genes, thereby facilitating the increased IMF deposition in muscle tissues [112]

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A likely explanation is that it supports energy production, which the brain needs