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Description

Trends Cardiovasc Med 16:6064

Isotopologue similarity between reaction-paired and non-reaction paired metabolites For each pair of two isotopically labeled known metabolites in 293T cells labeled with [U- 13 C]-glucose or [U- 13 C]-glutamine, we retrieved their metabolic reaction relationship from the metabolic reaction network

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Interestingly, SSBP1, a protein that is essential for mtDNA stability and replication during mitochondrial biogenesis, was increased by APOE4 in females and decreased by APOE4 in males, reflecting a sex-divergent response to APOE4 in the regulation of the same mitochondrial protein