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Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin

P21 Antibody was purchased from Invitrogen (MA5-14949)

Most chronic diseases of the CNS are associated with loss of function of astrocytes, and such loss of function is emerging as a leading mechanism of disorder-related neurological dysfunctions ranging from mild changes in synapse regulation to potential overt neurotoxicity in extreme cases

Next, we used the same CRISPR/Cas9-mediated gene silencing strategy to assess the role of the 44 nonessential human ABC transporters (Supplementary Fig

C., Recent insights into natural product inhibitors of matrix metalloproteinases, Med