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(83), using the first crystal structure of G6PD, showed that the substitution of Arg with Leu at a highly conserved amino acid area near to the NADP + binding site in G6PD Canton affects the stability of the molecule

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FGF21 analogs therefore represent a promising emerging class of NASH therapeutics, as a number of them have demonstrated pleiotropic effects consistent with improved liver health and whole-body metabolism

6 Limitation and Future perspective Although current research has revealed the critical role of ferroptosis in the pathological progression of AD, several limitations remain to be addressed in this field: (1) Existing evidence primarily relies on animal models or in vitro cellular experiments, failing to comprehensively reflect the spatiotemporal dynamics of iron metabolism dysregulation in the brains of human AD patients