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The agent (including cells) may be introduced into the desired site by direct injection or by any other means used in the art, including but not limited to intravascular, intracerebral, parenteral, intraperitoneal, intravenous, epidural, intraspinal, intrasternal, intraarticular, intrasynovial, intrathecal, intraarterial, intracardiac, or intramuscular administration

CagriSema data from body composition scans in REDEFINE 1 showed that approximately 67% of total weight loss came from fat mass and 33% from lean soft tissue mass

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Medications with poor oral absorption, low lipid solubility, and high protein binding are safest (Table 1 2 )

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