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Up to late-20th century, COPD was considered solely a smoking-related disease [21], and most research focused on the pathological and physiological changes in the airways and lungs caused by smoking

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Further, the data indicate that menthol in cigarettes is likely associated with greater addiction

We can ensure that the next generation of children in California do not become addicted to smoking, said Assemblymember Damon Connolly, a Democrat from San Rafael and the author of the bill

Also, the cigarette smoke resulted in accumulation of inflammatory cells in the lung parenchyma, increased secretion of mucus, goblet cell hyperplasia and alveoli enlargement