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Moreover, endothelial cells generate chemokines and adhesion molecules, promote the migration and adhesion of SMCs, aggravate vascular stenosis and plaque instability, promote vascular calcification, promote the precipitation of uric acid crystallization, increase blood viscosity, induce 5-HT release, increase platelet number and induce internal platelet activation

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Inhibiting HDAC1 lactylation at K412 facilitates the significant activation of FTO and ALKBH5, which reduces ferroptosis suppressor protein ( FSP1 ) mRNA m 6 A methylation in CRC cells