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Nitrosylating agents derived from nitric oxide can transiently form S-nitrosothiols (R-SNO), which act as activated intermediates that readily undergo further redox reactions, including disulfide bond formation

While our study design and statistical methods for association testing account for population structure to mitigate confounding, these inherent EHR biases may impact the overall power and generalizability of the findings across different ancestral groups

Levine RL, Mosoni L, Berlett BS, Stadtman ER

Genetic Factors Leading to Deficiency Genetic mutations can result in severe forms of glutathione reductase deficiency, with deficient subjects displaying electrophoretic polymorphisms linked to the deficiency

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