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The increase of intracellular blood glucose level leads to the increase of diacylglycerol (DG) synthesis and activation of PKC, thus inducing the production of the signal molecules such as endothelin-1 (ET-1), transforming growth factor-1 (TGF-1), interleukin-1 (IL-1) and reactive oxygen species (ROS) in kidney cells

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Toledo et al., 2017

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Melatonin activates the progenitor cell production of macrophages, NK cells, and granulocytes (98)