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Notably, the partially unfolded domain functions as a damage-associated molecular pattern (DAMP) molecule, driving the release of pro-inflammatory cytokines including TNF- and IL-8 from fibroblasts and activating the TLR4/NF-B pathway [156,157,158]

Dig Dis Sci 60(10):29632975 Miyazawa T, Matsumoto M, Kato S, et al (2003) Dopamine-induced protection against indomethacin-evoked intestinal lesions in rats--role of anti-intestinal motility mediated by D2 receptors

The beneficial effect of mitochondria-targeted drugs for kidney injury has been shown in several animal models (Table 2)

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