Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE AHPC 638 Purity (HPLC) >= 95%

638 Purity (HPLC) >= 95% Solubility DMSO

Product Name DOTA-C4-azide Synonyms CAS Number n/a Related CAS Molecular Formula C20H36N8O7 Molecular Weight 500

411 SMILES OCCCCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

S)-AHPC-CO-C10-acid Synonyms CAS Number 2357115-09-2 Related CAS Molecular Formula C34H50N4O6S Molecular Weight 642

The Val–Cit sequence is selectively cleaved by cathepsin B in lysosomes

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE AHPC 638 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to