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in 30 healthy Filipino women (aged 2242 years) with Fitzpatrick skin types IV or V, using buccal lozenges instead of capsules of GSH, reported significant reduction in melanin index at both sun-exposed and sun-protected sites in all the subjects and moderate skin lightening observed by 90% of the subjects on global evaluation [11]

Other factors proposed in the pathogenesis of IBD include an initial breakdown of the epithelial barrier which can lead to a self-amplifying cycle of immune activation and cytokine release [79], and loss of tolerance to endogenous microflora and dietary antigens [82,87]