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Conversely, dysregulated Kla renders extensive impacts on the pathogenesis of various diseases, including cancer, neuropsychiatric disorders, cardiovascular and ophthalmic diseases, and immunoinflammatory and metabolic dysregulation, through modulating immune homeostasis, metabolic adaptation, and epigenetic remodeling

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Future success will depend on leveraging strong preclinical evidence while prioritizing clinical trial designs that rigorously assess long-term outcomes

26 , 300306.e9 (2019)