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2 The native hormone has a serious pharmaceutical liability: it is prone to aggregation into amyloid fibrils and has a plasma half-life measured in minutes, which is why the first amylin-based drug, pramlintide, had to be injected before every major meal

J Inorg Biochem 1(163):1827 Gallegos KM, Drusano GL, DArgenio DZ, Brown AN (2016) Chikungunya virus: in vitro response to combination therapy with ribavirin and interferon alfa 2a