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Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth

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The activation of macrophages and HMGB1, as well as neutrophil infiltration, can promote the inflammatory chain reaction of surrounding cells, causing an excessive immune response and tissue damage that eventually leads to severe COVID-19 and an increased risk of ARDS (39, 4244, 75)