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Traditional obesity intervention strategies (e.g., dietary control, exercise, conventional weightloss drugs) are often limited by slow onset, obvious side effects, and high rebound rates, and can hardly fundamentally reverse the abnormal metabolic phenotype of adipose tissue

Here are some common scenarios: Initial Treatment Phase: In the initial phase of treatment, injections may be administered more frequently, such as daily or weekly, until B12 levels are restored

Reconstituting with larger solvent volumes (45mL) improves measurement precision for low doses but depletes the vial faster across multiple injections

The larger, longer trial failed to show significant results at all