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The issue arises when a clinician monitoring renal safety during GHK-Cu therapy sees a rising creatinine and misattributes it to copper-mediated nephrotoxicity

Routine vitamin B12 testing should be conducted, especially in those over age 60 and in those on medications such as acid reducers, birth control pills, and diabetic medicationmost who are deficient need vitamin B12 supplementation

Neeb H, Ermer V, Stocker T, Shah NJ

When intracellular free iron levels increase, the intracellular labile iron pool also increases (3)

Application site reactions such as a burning sensation and application site pain have been reported as side effects of capsaicin patch [73-75]