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[221] initially fabricated a PDA coating on the surface of a calcium phosphate cement scaffold before covalently grafting chondroitin sulfate onto the PDA layer using adipic acid dihydrazide to bind BMP-2 for bone regeneration

Because peptides are rapidly cleaved by proteases, intact BPC-157 rarely persists beyond 812 hours post-dose

Because these peptides work by promoting cell growth and angiogenesis (the formation of new blood vessels), there is a concern they could speed up the growth of existing , undiagnosed tumors by feeding them a new blood supply

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