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Collagen peptides have more human data on knee osteoarthritis symptoms, but even there, results are mixed and effect sizes are often modest

Chanasit S, Johnston E, Thanasarnthungcharoen C, Kamath SD, Bohle B, Lopata AL et al (2024) Hypoallergenic chimeric virus-like particles for the development of shrimp tropomyosin allergen Pen m 1-specific blocking antibodies

Curr Biol 10(11):640648 Hedayati N, Safari MH, Milasi YE, Kahkesh S, Farahani N, Khoshnazar SM et al (2025) Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity

It also promotes sun tanning, forms freckles and age spots, and causes uneven pigment in some people

In one human study that showed improvements in kidney stones, the daily dosage was 4.5 grams of chanca piedra infused in one cup of hot water twice daily for 12 weeks ( Chanca piedra pills or capsules contain anywhere from 500 to 1,600 mg of the herb per dose, and liquid extracts contain a similar amount