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bupropion, nortriptyline or varenicline) Plans to stop smoking before or at the annual review Currently enrolled in another smoking-related study or other study where the aims of the studies are incompatible Cannot consent due to mental incapacity Pregnant, breastfeeding or planning to become pregnant during the course of the study Withdrawal criteria Each participant has the right to withdraw from the trial at any time

Reference Jiang Y, Mingard C, Huber SM, Takhaveev V, McKeague M, Kizaki S, Schneider M, Ziegler N, Hrlimann V, Hoeng J, Sierro N, Ivanov NV, Sturla SJ: Quantification and Mapping of Alkylation in the Human Genome Reveal Single Nucleotide Resolution Precursors of Mutational Signatures

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