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Control systems must be designed to provide early warnings of system changes and enable corrective action before performance is affected

J Immunother 33(9):991998 Martino EC et al (2016) Immune-modulating effects of bevacizumab in metastatic non-small-cell lung cancer patients

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Any change in appearance, including crystallization, precipitation, or color change, indicates that the medication should not be used and should be returned to the pharmacy for proper disposal