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Three-dimensional (3D) brain organoids are formed from a mixture of human iPSCs-derived neurons and glial cells cultured using artificial matrices that resemble the extracellular matrix (e.g., matrigel) and can mature in a more physiologically relevant microenvironment, closely mimicking the complexity of cellular interactions in the brain

10.1016/j.neurobiolaging.2015.02.016 Neurobiol

Ultimately, this leads to an OXPHOS reaction, providing energy for the organism

Tsai and Coyle, 1995), the observed increase may reflect higher neuronal viability and, therefore, possibly higher insular activity, further supporting the aforementioned theory

J Biol Chem 291:2024720259