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GSH in fact is both a nucleophile and a reductant, and therefore can react with electrophilic or oxidizing species rendering the former molecules more soluble and excretable, and the latter unable to interact with more critical cellular constituents such as lipids, nucleic acids and proteins

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Ultrastructural features of aberrant glial cells isolated from the spinal cord of paralytic rats expressing the amyotrophic lateral sclerosis-linked SOD1G93A mutation