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Form: high-affinity, weightless gelfluid serum

The volume ratio of the eluents A and B, A/B, was changed linearly from 100%/0% to 0%/100% during 0 to 16 min, kept 0%/100% during 16 min to 23 min, and then changed fast linearly from 0%/100% to 100%/0% during the next 1 min

Am J Biopharm Pharm Sci 2022;2:8

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By correlating structural data with biochemical activities, we find that Ran-GTP, but not Ran-GDP, constrains the solenoid structure of importin , closing high-affinity FG-binding pockets and displacing import cargos through allosteric crosstalk between the concave and convex surfaces