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[DOI] [PubMed] [Google Scholar] 116.Yamamoto A., Shin R.W., Hasegawa K., Naiki H., Sato H., Yoshimasu F., Kitamoto T

Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapy

Oxalate is a terminal metabolite produced from glyoxylate by hepatic lactate dehydrogenase (LDHA)

To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig