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Specifically, resveratrol regulates the JAML/SIRT1 lipid synthesis pathway through elevating the SIRT1 expression to reduce the expressions of SREBP-1 and ChREBP protein, further mitigating lipid deposition mediated by SREBP-1 and ChREBP, improving renal pathology and renal function in DKD patients and HFD-induced DKD mice ( Resveratrol attenuates mononuclear cell infiltration, smooth muscular cell migration, renal vessel sclerosis, and tubulointerstitial fibrosis induced by inflammation and oxidative stress after renal transplantation by regulating the SIRT1/FoxO1 signaling pathway to improve renal inflammation and oxidative stress injury

[DOI] [PubMed] [Google Scholar] 15.Chaitrakoonthong T., Kamolratanakul P., Ampornaramveth R

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2001;163(3 Pt 1):74552

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