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Large scale studies have demonstrated the importance of attempting to return to sub-symptom cardiovascular activity following concussion

in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation

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To isolate excitatory (AMPA-mediated) postsynaptic currents (EPSC), the GABA-A receptor inhibitor picrotoxin (PTX, 50 M) and AP-5 were added to the bath solution