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doi: 10.3389/fnins.2023.1203514 273 TappZMGodboutJPKokiko-CochranON

It arises from dysregulation of cell proliferation and concomitant genomic modifications ( Quercetin (QUE) is a flavonol compound that is insoluble in water but soluble in alcohol and lipids ( in vitro and in vivo studies have demonstrated the effects of QUE in cancer treatment

Moreover, S6K1 phosphorylates carbamoyl-phosphate synthetase (CAD) to activate the de novo pyrimidine synthesis pathway [46]

and plays an important role in sustaining life

Chatterjee SN stated that the permeability of the membrane has also been found to be increased in parallel with the lipid peroxidation indicating that the interior of the membrane undergoes alterations [17].Wolff SP et al stated that free radicals and oxidative stress may act as a common pathway to diabetes itself as well as to its later complications & found significantly higher lipid peroxide levels in diabetic than healthy individuals, matching our study results [18]