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Tosti, A., Piraccini, B

This section delineates the core cellular stress pathwaysincluding endoplasmic reticulum stress, oxidative stress, mitophagy dysfunction, and epigenetic reprogrammingthat drive pulmonary injury in diabetes at the molecular level (Figure 3)

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This suggests that the RBC coating helps preserve the enzymatic activity and efficiency of uricase in degrading uric acid

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