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Aging, environmental toxins, chronic stress, and disease states are all associated with declining GSH levels and a shift toward the oxidised form

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In addition, lipid disorders affect SREPB-1 expression, resulting in lipid deposition in the trabecular meshwork, causing lectin-like oxidized LDL receptor-1 (Lox-1) uptake of oxidized LDL, activation of the NF-kB signaling pathway, and elevated expression of IL-6 and TNF-, resulting in inflammatory damage to the optic nerve

[DOI] [PubMed] [Google Scholar] 62.Castiglia P., Sanna V., Azara A., De Miglio M.R., Murgia L., Pira G., Sanges F., Fancellu A., Carru C., Bisail M., et al